The College of San Gregorio is – following its restoration and the modernisation of its facilities in 2009 – one of the two main buildings housing the Museum's permanent exhibition. It is home to the historical collection consisting of work by great Spanish masters from the 15th to the 18th century who created sculptures of polychrome wood, which served a devotional or liturgical function.
In 2011 the Ministry of Culture began the restoration of the Casa del Sol (House of the Sun) in the annex of the Church of San Benito el Viejo to exhibit the collection of 19th and 20th century copies from the former National Museum of Artistic Reproductions in Madrid. This expansion doubled the content of the Museum (from 3,000 artworks to 6,000) and redefined its concept.
Aware of the need to adapt to social demand, the Museum designated a third site – the Palacio de Villena – to hold temporary exhibitions, educational activities, and public programmes. It now houses the library, archives, photography and restoration workshops, the 18th-century Neapolitan nativity scene, and the auditorium.